100% Original Cryptococcus Molecular Detection Kit (Real-time PCR) - Carbapenem-resistant OXA-48 Detection K-Set (Lateral Flow Assay) – Genobio

Product Introduction

The Carbapenem-resistant OXA-48 Detection K-Set (Lateral Flow Assay) is an immunochromatographic test system intended for the qualitative detection of OXA-48-type carbapenemase in bacterial colonies. The assay is a prescription-use laboratory assay which can aid in the diagnosis of OXA-48-type carbapenem resistant strains.

Characteristics

Advantage

• Rapid
  Obtain result within 15 min, 3 days earlier than traditional detection methods
• SOXA-48le
  Easy to use, ordinary laboratory staff can operate without training
• Accurate
  High sensitivity and specificity
  Low detection limit: 0.10 ng/mL
  Able to detect most of the common subtypes of OXA-48

• Intuitive result
  There is no need for calculation, visual reading result
• Economic
  Product can be transported and stored at room temperature, reducing costs

The importance of CRE test

CRE, which stands for carbapenem-resistant Enterobacteriaceae, are a family of germs that are difficult to treat because they are highly resistant to antibiotics. Klebsiella species and Escherichia coli (E. coli) are examples of Enterobacteriaceae, a normal part of the human gut bacteria that can become carbapenem-resistant. The reason why CREs are resistant to carbapenems is because they produce carbapenemases.

Clinicians play a critical role in slowing the spread of CRE. Usually, they can help prevent the spread of CRE by

• Know if patients with CRE are hospitalized at or transferred to the facility, and stay aware of CRE infection rates.
• Place patients currently or previously colonized or infected with CRE on Contact Precautions.
• Make sure labs immediately alert clinical and infection prevention staff when CRE are identified
• Prescribe and use antibiotics wisely
• Discontinue invasive devices as soon as no longer necessary

……
Rapidly identifying patients colonized or infected with these organisms and placing them in Contact Precautions when appropriate, using antibiotics wisely, and minimizing device use are all important parts of preventing CRE transmission, which means a rapid and accurate detection of CRE is very necessary.

OXA-48-tye carbapenemase

Carbapenemase refers to a type of β-lactamase that can at least significantly hydrolyze imipenem or meropenem, including A, B, D three types of enzymes classified by Ambler molecular structure. Class D, such as OXA-type carbapenemase, were frequently detected in Acinetobacteria. Surveillance studies have shown that OXA-48-type carbapenemases, also known as oxacillinase-48-like beta-lactamase, are the most common carbapenemases in Enterobacterales in certain regions of the world and are being introduced on a regular basis into regions of nonendemicity, where they are responsible for nosocomial outbreaks.

Operation

• Add 5 drops of sample treatment solution
• Dip bacterial colonies with a disposable inoculation loop
• Insert the loop into the tube
• Add 50 μL to the S well, wait for 10-15 minutes
• Read the result

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